GRACE

ACS RISK SCORE

University of Edinburgh

ACS RISK SCORE

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ACS RISK SCORE

Development

Development of GRACE Risk Version 2.0 Score

In 2012 the Centre for Cardiovascular Science, University of Edinburgh, in collaboration with the Center for Outcomes Research, University of Massachusetts further developed the original GRACE Risk Score Development involved modification of 2 of the original 8 clinical variables used to calculate the score. Diuretic usage was substituted for Killip Class, and renal failure for creatinine level. In addition, the time of the estimation of the risk period was extended from 6 months to 1 year and 3 years. Simplified, but still retaining comparable predictive ability to the original model, the GRACE Risk Version 2.0 Score now predicts the outcomes of death, and death or MI over an extended 1 year and also death over a 3 year period from hospital admission. This updated version of the GRACE Risk Score has been independently validated with data from the French FAST-MI Registry (European Society of Cardiology Congress 2013).16

Development of the GRACE Risk Version 2.0 Score was supported by research grants from the British Heart Foundation, Chief Scientist Office Scotland, and AstraZeneca. The main GRACE programme was supported by an educational grant from Sanofi-Aventis to the Center for Outcomes Research, University of Massachusetts.